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KMID : 0613820080180111584
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Journal of Life Science
2008 Volume.18 No. 11 p.1584 ~ p.1591
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Hypoglycemic Effect of Chlorella sp. CMS-1 Hot Water Extract on Streptozotocin-Induced Diabetic Rats
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Kim Jung-Wook
Cha Jae-Young
Heo Jin-Sun
Jin Hyun-Jin
Cho Young-Su
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Abstract
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The effect of Chlorella hot water extract (CE) on hyperglycemia in streptozotocin-induced diabetic rats has not been studied. Therefore, hypoglycemic effect of CE in type I streptozotocin-induced diabetic rats was studied. Rats were fed a semisynthetic diet supplemented with either 3% (the STZ+CE3) and 6% (the STZ+CE6) CE or no supplement the Normal and the STZ-Control rats for 4 weeks. The concentrations of fasting and non-fasting blood glucose were higher in the STZ-Control rats than in the Normal rats, but this rise was lowered in the STZ+CE3 and the STZ+CE6 rats. Serum insulin concentrations were decreased with STZ injection, however, the decreased levels were almost restored to the Normal level with CE supplementation. The increased serum fructosamine levels associated with hyperglycemia were decreased with the CE treatment. The morphology of pancreatic islets in the Normal rat was round and maintained a typical arrangement. The STZ-Control pancreatic beta-cells were found to have significant swelling and severely morphological damaged, however, pancreatic tissue damage by STZ in the CE-supplemented diet group was ameliorated. This study shows that Chlorella hot water extract had a hypoglycemic effect on the STZ-diabetic rats via either increased insulin secretion during recovery or the prevention of STZ-induced pancreatic damage.
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KEYWORD
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Chlorella sp, CMS-1, diabetes, hypoglycemia, pancreatic islets, streptozotocin
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